Familial macrocytosis
نویسندگان
چکیده
منابع مشابه
Evaluation of macrocytosis.
Macrocytosis, generally defined as a mean corpuscular volume greater than 100 fL, is frequently encountered when a complete blood count is performed. The most common etiologies are alcoholism, vitamin B12 and folate deficiencies, and medications. History and physical examination, vitamin B12 level, reticulocyte count, and a peripheral smear are helpful in delineating the underlying cause of mac...
متن کاملTyrosine kinase inhibitor-induced macrocytosis.
BACKGROUND The tyrosine kinase inhibitors (TKI) sunitinib and imatinib were shown to induce macrocytosis in patients with renal cell cancer (RCC) and gastrointestinal stromal tumors (GIST), presumably through inhibition of the c-KIT dependent signaling pathway of erythroid progenitor cells of the bone marrow. PATIENTS AND METHODS Hematology charts of patients with RCC, breast cancer (BC), GIS...
متن کاملUnexplained macrocytosis in elderly patients.
One hundred and twenty-four patients over the age of 75 years were assessed for the cause of their macrocytosis (MCV > 95 fl). A definitive diagnosis was reached in 75/124 (60%) by non-invasive techniques. The remainder underwent a bone marrow biopsy yielding a definitive diagnosis in a further six patients who had an identifiable myelodysplastic syndrome (MDS). A high proportion of the remaind...
متن کاملThe Macrocytosis of Hepatic Disease
By JoHN BINGHAM I HE BLOOD OF PATIENTS with hepatic disease frequently contains macrocytic red blood cells. Since their recognition in 1883,i numerous papers have been written about them, but there is still no agreement on the frequency, morphology, etiology or clinical significance of these large cells. The purpose of this study was to re-examine this problem by studying a large group of patie...
متن کاملMacrocytosis as an indicator of human disease.
Adult patients with macrocytosis, defined as a mean corpuscular volume (MCV) greater than 100 femtoliters, were studied to assess the importance of an elevated MCV. After eliminating pregnant and postpartum patients and patients receiving medications known to cause macrocytosis (e.g., phenytoin, zidovudine, and chemotherapeutic agents), 80 patients were identified and studied. Sixty-seven diagn...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1994
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.2830460323